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Match preview
Since their first encounter 134 years ago, these two great clubs have met 122 times, most famously doing so in the 1889 FA Cup Final, with Preston running out 3-0 winners at Kennington Oval.
Now, they’ll meet for the first time since 2018, in a game that’s unlikely to be as historic as that.
Wolverhampton Wanderers will see this tie as a great opportunity to claim their first victory of the season.
So far, Bruno Lage’s team have just one point from three Premier League outings, beaten 1-0 at Tottenham on Saturday, despite dominating for long periods.
In League Cup terms, Wolves haven’t gone beyond round four since 2011, so would love an extended run in the competition.
Preston North End meantime hammered Huddersfield Town 4-1 in the previous round.
In the Championship, Ryan Lowe’s team are up in ninth, having held Watford to a goalless draw at the weekend.
So, the Lilywhites will fancy their chances of reaching round three for the fifth successive season.
Will Molineux witness a Premier League side crashing out in round two?