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Match preview
Having claimed a narrow victory in the first leg, can Ludogorets make the most of that advantage, as they travel 1,150 miles north-west to Brussels?
A week ago, the only goal of the night at Huvepharma Arena was scored by 21 year old Brazilian forward Thiago with just nine minutes on the clock.
Having won 11 consecutive Bulgarian titles, Ludogorets have featured in nine UEFA group stages in the past ten seasons.
However, the Eagles have lost their last four knockout phase ties, ousted by Valencia, København, A.C. Milan and Inter since their sole victory over Lazio nine years ago.
Given that Ludogorets have been beaten in 12 of their last 22 European away games, winning just four, this is far from a forgone conclusion.
Hosts Anderlecht meanwhile are all the way down in ninth in the Jupiler Pro League, so are looking to continental competition to salvage their campaign.
So, this clash at Stade Constant Vanden Stock is finely poised.
Anderlecht team news
Centre-back Hannes Delcroix and midfielder Marco Kana are both out injured.
Captain Jan Vertonghen is set to make his 127th appearances in UEFA competition.
Panamanian right-back Michael Murillo, who scored against KV Kortrijk on Sunday, leads the Europa Conference League for yellow cards this season, having racked up five in just six appearances.
Ludogorets Razgrad team news
Centre-back Olivier Verdon is serving the second of his three-game ban, having been sent off at Stadio Olimpico in November.
Captain Anton Nedyalkov and Jakub Piotrowski also missed the first leg suspended, but both are likely to return here.
Brazilian winger Rick, who scored in that aforementioned defeat to Roma, has since torn his knee ligaments.
Anderlecht vs Ludogorets Razgrad: Head to head statistics
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