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Recommended bets
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Match preview
Having claimed a commanding lead at Old Trafford last Thursday, Manchester United travel to Seville firmly in pole position to advance.
A week ago, Marcus Rashford spectacularly broke the deadlock after just five minutes, only for Ayoze Pérez to equalise with a stunning outside the foot strike.
Nevertheless, Man United then ran riot in the second half, with Antony, Bruno Fernandes and Wout Weghorst all on target, thereby securing a 4-1 win.
Only once before have the Red Devils failed to get through when winning a first leg by 3+ goals, this coming against Sporting CP in the Cup Winners’ Cup 60 years ago.
So, to say Erik ten Hag’s team have one foot in the quarter-finals would be an understatement.
Despite drawing 0-0 with Southampton at the weekend, Man United remain third in the Premier League, meaning this competition, alongside the FA Cup, should take priority.
As for Real Betis, their wait for a first European quarter-final appearance since 1998 is set to go on.
Their focus will firmly shift back to La Liga where los Verdiblancos are fifth, targeting a first top four finish in 18 years.
Can Manuel Pellegrini’s men pull off a remarkable comeback or will Man United be celebrating come full time at Estadio Benito Villamarín?
Real Betis team news
Star midfielder Nabil Fekir will miss the rest of the season while Sergio Canales, who’s been carrying an injury, wasn’t risked in the first leg at Old Trafford.
Top-scorer Borja Iglesias was also left on the bench last mid-week, with Willian José rotated in, showing that Manuel Pellegrini is prioritising domestic matters.
One man who did start the first leg is Joaquín who, at 41 years old, become the competition’s old goal scorer during the group phase.
Predicted XI (4-3-3): Bravo; Sabaly, Germán, Luiz Felipe, Abner; Carvalho, Rodríguez, Joaquín; Luiz Henrique, Ayoze Pérez, José.
Manchester United team news
Given that they’re three goals to the good, and have an FA Cup quarter-final with Fulham on Sunday, Erik ten Hag will surely rotate at least a bit here.
This could see Diogo Dalot, Tyrell Malacia or even Harry Maguire come into the back-line.
Alejandro Garnacho was spotted leaving Old Trafford on crutches at the weekend, so is unlikely to feature.
Casemiro, who’s about to start a four-game domestic ban, would also miss the quarter-final first leg if booked here.
Predicted XI (4-3-3): de Gea; Dalot, Maguire, Martínez, Malacia; Casemiro, Fred, Fernandes; Antony, Sancho; Weghorst.
Real Betis vs Manchester United: Head to head statistics
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