Manchester United will take on Spanish side Real Sociedad while Tottenham face AZ Alkmaar in the Europa League last-16.
The two English clubs finished third and fourth respectively in the league phase and will both fancy their chances of progressing to the quarter-finals.
Meanwhile, Rangers face the tough task of battling Jose Mourinho and Fenerbahce, after the Turkish side came through the play-off round.
Roma and Athletic Club match up in another tasty tie while Eredivisie giants Ajax go head-to-head with Frankfurt.
The two-legged ties will take place in the weeks of 4 March and 11 March.
There will be no further draws for the rest of the competition as the matches are all in a seeded bracket.
Should Manchester United progress, they will face Lyon or FCSB in the quarter-finals.
Spurs would face the winners of Ajax and Frankfurt.
🚨🏆 Who’s gonna win Europa League?@ActuFoot_ 📸🎨 pic.twitter.com/XCTaZyO9il
— Fabrizio Romano (@FabrizioRomano) February 21, 2025
Europa League last-16 draw in full
Bodo/Glimt vs Olympiacos
Fenerbahce vs Rangers
Ajax vs Frankfurt
FCSB vs Lyon
AZ Alkmaar vs Tottenham
Real Sociedad vs Manchester United
Viktoria Plzen vs Lazio
Roma vs Athletic Club
