Benfica head into the game with one foot in the quarter-finals of the Champions League.
The Portuguese outfit secured a 2-0 win in the first leg in Belgium thanks to goals from Joao Mario and David Neres.
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Predicted Benfica line-up vs Club Brugge
Benfica team news vs Club Brugge
Benfica have a few injury concerns heading into the second leg.
Mihailo Ristic (muscle) and Julian Draxler (ankle) are both sidelined, while midfielder Chiquinho is nursing a muscular problem and will also likely miss out.
Elsewhere, Wolves loanee Goncalo Guedes is unlikely to be risked as he is dealing with a sore knee.
Who has kept the most clean sheets in a single Premier League season?