Inter Milan head into the game boosted by their result in the first leg.
The Italian outfit were able to secure a 1-0 win at the San Siro last time out thanks to an 86th-minute strike from Romelu Lukaku.
Predicted Inter Milan line-up vs FC Porto
Inter Milan team news vs FC Porto
Inter Milan do not have too many injury concerns heading into the second leg.
Joaquin Correa could be back in contention for Inter after his recent return to training.
However, centre-back Milan Skriniar is expected to miss the game with a back problem but could return this weekend.