Arsenal and Manchester City had not faced off at all in 2022/23 before Friday evening.
So with two huge league games still to play out, the Gunners will have been keen to get one over on their title rivals to boost their confidence.
However, when all was said and done, a Nathan Ake strike in the second half was enough to put Manchester City into the next round.
Now, following the game, Mikel Arteta has explained why Arsenal lost.
Speaking to ITV shortly after the loss Arteta said: “Really disappointed. I think we could have got much more out of the game. The action decided the game but it was a tight game and that one action changed it all. I think we could have dealt with it much better in terms of our discipline when the ball was in the box.
“We had big situations in the game and we didn’t put them away. We can take a lot of positives, I think the way we approached the game and competed. It is really difficult to win against this team but we went head to head with them.
Manchester United vs Reading betting tips: FA Cup preview prediction and odds
Cremonese vs Inter Milan betting tips: Serie A preview, prediction and odds
